Posted: Jul 31, 2018
| Name | School | Years | GP | Att | Yards | YPC | YPG | TD |
| 1-Jason Brader | Muhlenberg | 1997-98 | 20 | 548 | 2,684 | 4.90 | 134.20 | 19 |
| 2-Eric Frees | McDaniel | 1988-91 | 40 | 1,059 | 5,281 | 4.99 | 132.03 | 45 |
| 3-Paul Smith | Gettysburg | 1996-99 | 40 | 881 | 5,205 | 5.91 | 130.13 | 49 |
| 4-Ray Condren | Gettysburg | 1983-84 | 20 | 517 | 2,543 | 4.92 | 127.15 | 22 |
| 5-Joe Rollins | McDaniel | 2010-13 | 38 | 774 | 4,641 | 6.00 | 122.13 | 34 |
| 6-Tom Sturges | Gettysburg | 2004-07 | 36 | 938 | 4,312 | 4.60 | 119.78 | 30 |
| 7-Mike Birosak | Dickinson | 1986-89 | 39 | 1,112 | 4,662 | 4.19 | 119.54 | 47 |
| 8-Dwayne Marcus | Gettysburg | 1991-94 | 33 | 690 | 3,852 | 5.58 | 116.73 | 32 |
| 9-Bill Sedgwick | Ursinus | 1991-93 | 28 | 603 | 3,267 | 5.42 | 116.68 | 26 |
| 10-Andrew Kase | Johns Hopkins | 2006-09 | 42 | 931 | 4,494 | 4.83 | 107.00 | 44 |
| 11-Chris Negron | Moravian | 2013-16 | 41 | 855 | 4,355 | 5.09 | 106.22 | 39 |
| 12-Shearrod Duncan | Ursinus | 1999-01 | 28 | 530 | 2,952 | 5.57 | 105.43 | 34 |
| 13-Matt Bernardo | Muhlenberg | 2000-03 | 40 | 849 | 4,117 | 4.85 | 102.93 | 60 |
| 14-Nick Savant | Muhlenberg | 2014-17 | 28 | 475 | 2,855 | 6.01 | 101.96 | 29 |
| 15-John DeLuca | Muhlenberg | 2005-08 | 41 | 895 | 4,041 | 4.52 | 98.56 | 35 |
| 16-Ken Clark | Swarthmore | 1999-00 | 18 | 452 | 1,717 | 3.80 | 95.39 | 2 |
| 17-Alex Plomaritis | Dickinson | 1989-92 | 33 | 563 | 2,900 | 5.15 | 87.88 | 40 |
| 18-Kyle Wigley | Gettysburg | 2012-15 | 29 | 450 | 2,546 | 5.66 | 87.79 | 14 |
| 19-Rob Johnson | McDaniel | 1989-93 | 39 | 700 | 3,405 | 4.86 | 87.31 | 37 |
| 20-Ted Delia | Gettysburg | 2009-12 | 22 | 366 | 1,908 | 5.21 | 86.73 | 25 |